International Tables for Crystallography

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The preparation of heavy-atom derivatives of protein crystals for use in multiple isomorphous replacement and anomalous scattering
D. Carvin, S. A. Islam, M. J. E. Sternberg and T. L. Blundell. International Tables for Crystallography (2006). Vol. F, ch. 12.1, pp. 247-255  [ doi:10.1107/97809553602060000679 ]

Abstract

In this chapter an introduction to the heavy-atom data bank is provided and strategies are reviewed that can be adopted in the preparation of heavy-atom derivatives of protein crystals for use in multiple isomorphous replacement and anomalous scattering. Topics covered include: heavy-atom derivatives and their complexes; amino acids as ligands; the protein chemistry of heavy-atom reagents; metal-ion replacement in metalloproteins; analogues of amino acids; and the use of the heavy-atom data bank to select derivatives.


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About International Tables for Crystallography

International Tables for Crystallography is the definitive resource and reference work for crystallography. The multi-volume series comprises articles and tables of data relevant to crystallographic research and to applications of crystallographic methods in all sciences concerned with the structure and properties of materials.