International
Tables for
Crystallography
Volume F
Crystallography of biological macromolecules
Edited by M. G. Rossmann and E. Arnold

International Tables for Crystallography (2006). Vol. F. ch. 17.2, p. 365   | 1 | 2 |

Figure 17.2.5.1 

A. J. Olsona*

aThe Scripps Research Institute, La Jolla, CA 92037, USA
Correspondence e-mail: olson@Scripps.edu

[Figure 17.2.5.1]
Figure 17.2.5.1

This image represents a volume of blood plasma 750 Å on a side. Within the three-dimensional model, antibodies (Y- and T-shaped molecules in light blue and pink) are binding to a virus (the large green spherical assembly on the right), labelling it for destruction. It shows all macromolecules present in the blood plasma at a magnification of about 10 000 000 times. This model is composed of over 450 individual protein domains, ranging in size from the 60 protomers making up the poliovirus to a single tiny insulin molecule (in magenta). The model was constructed using atomic level descriptions for each molecule, for a total of roughly 1.5 million atoms. Detailed surfaces were computed for each type of protein using MSMS by Michel Sanner and then smoothed to a lower resolution using the HARMONY spherical-harmonic surfaces developed by Bruce Duncan. The model geometry contains over 1.5 million triangles.