Table 1.3.4.4

International
Tables for
Crystallography
Volume F
Crystallography of biological macromolecules
Edited by M. G. Rossmann and E. Arnold

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International Tables for Crystallography (2006). Vol. F. ch. 1.3, p. 20

W. G. J. Hol^a ^* and C. L. M. J. Verlinde^a

^aBiomolecular Structure Center, Department of Biological Structure, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195-7742, USA
Correspondence e-mail: hol@gouda.bmsc.washington.edu

Table 1.3.4.4 | top | pdf |
Mechanisms of resistance

Overexpress target protein

Mutate target protein

Use other protein with same function

Remove target altogether

Overexpress detoxification enzyme

Mutate detoxification enzyme

Create new detoxification enzyme

Mutate membrane porin protein

Remove or underexpress membrane porin protein

Overexpress efflux pumps

Mutate efflux pumps

Create/steal new efflux pumps

Improve DNA repair

Mutate prodrug conversion enzyme