Figure 23.2.2.1

Hodel, A. E.; Quiocho, F. A.

doi:10.1107/97809553602060000715

International
Tables for
Crystallography
Volume F
Crystallography of biological macromolecules
Edited by M. G. Rossmann and E. Arnold

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International Tables for Crystallography (2006). Vol. F. ch. 23.2, p. 579 | 1 | 2 |

Figure 23.2.2.1

A. E. Hodel^a ^‡ and F. A. Quiocho^b

^aDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA, and ^bHoward Hughes Medical Institute and Department of Biochemistry, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA

Figure 23.2.2.1

The atomic recognition of carbohydrates by a protein. The environment of glucose bound to the galactose/glucose binding protein is shown (Vyas et al., 1988). (a) The ring of hydrogen bonds around the polar edge of the sugar molecule. Note the `bidentate' hydrogen bonds with Asp236, Arg158 and Asn91. As the hydroxyl groups 1, 2 and 3 simultaneously donate and accept hydrogen bonds from protein side chains, they are involved in `cooperative' hydrogen bonds. (b) Two aromatic protein side chains, Phe16 and Trp183, `stack' on the non-polar faces of the carbohydrate.