Figure 23.3.3.5

Dickerson, R. E.

doi:10.1107/97809553602060000716

International
Tables for
Crystallography
Volume F
Crystallography of biological macromolecules
Edited by M. G. Rossmann and E. Arnold

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International Tables for Crystallography (2006). Vol. F. ch. 23.3, p. 600 | 1 | 2 |

Figure 23.3.3.5

R. E. Dickerson^a ^*

^a Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095–1570, USA
Correspondence e-mail: red@mbi.ucla.edu

Figure 23.3.3.5

The role of the C2′-OH in RNA helix geometry. (a) Addition of a C2′-OH group (*) to the B-DNA helix leads to close contacts and unallowable steric hindrance with the following O5′ and O4′ atoms and, to a lesser degree, the subsequent base itself. (b) A C2′-OH group added to the A-DNA helix extends outward radially from the helix cylinder surface and produces no steric clashes. Hence, A-RNA is quite possible, whereas B-RNA is disallowed.