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International
Tables for Crystallography Volume F Crystallography of biological macromolecules Edited by M. G. Rossmann and E. Arnold © International Union of Crystallography 2006 |
International Tables for Crystallography (2006). Vol. F. ch. 25.2, p. 721
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Starting from a molecular-replacement solution implies that a search model positioned in the new lattice is already available. The model can be directly incorporated in restrained ARP refinement. If the starting model is very incomplete or different, its atoms can be regarded as free atoms and the solution can be treated as starting from just initial phases. This increases the radius of convergence and minimizes the bias introduced by the search model.
