The o-mercurihydroxytoluene p-sulfonate (MHTS) derivative

Blake, C. C. F.; Fenn, R. H.; Johnson, L. N.; Koenig, D. F.; Mair, G. A.; North, A. C. T.; Oldham, J. W. H.; Phillips, D. C.; Poljak, R. J.; Sarma, V. R.; Vernon, C. A.

doi:10.1107/97809553602060000725

International
Tables for
Crystallography
Volume F
Crystallography of biological macromolecules
Edited by M. G. Rossmann and E. Arnold

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International Tables for Crystallography (2006). Vol. F. ch. 26.1, p. 747 | 1 | 2 |

Section 26.1.2.4.3. The o-mercurihydroxytoluene p-sulfonate (MHTS) derivative

C. C. F. Blake,^a ^‡ R. H. Fenn,^a ^§ L. N. Johnson,^a ^*^¶ D. F. Koenig,^a ^‡‡ G. A. Mair,^a ^‡‡ A. C. T. North,^a ^§§ J. W. H. Oldham,^a ^¶¶ D. C. Phillips,^a ^¶¶ R. J. Poljak,^a ^‡‡‡ V. R. Sarma^a ^§§§ and C. A. Vernon^b ^¶¶

^a Davy Faraday Research Laboratory, The Royal Institution, London W1X 4BS, England, and ^bDepartment of Chemistry, University College London, Gower Street, London WC1E 6BT, England
Correspondence e-mail: louise@biop.ox.ac.uk

26.1.2.4.3. The o-mercurihydroxytoluene p-sulfonate (MHTS) derivative

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The hk0 difference-Patterson map of the p-mercuribenzene sulfonate (PCMBS) derivative was interpretable in terms of a single site of substitution at 8 Å resolution, but it was not useful beyond about 8 Å because of lack of isomorphism. RJP and RHF then explored the usefulness of MHTS as a derivative. This compound had been specially synthesized by JWHO in the hope that a small rearrangement of groups present in PCMBS would lead to an isomorphous derivative. Happily, this strategy worked, and MHTS gave a useful isomorphous derivative in which the major site overlapped that of PCMBS (Fig. 26.1.2.3).

Figure 26.1.2.3| top | pdf |

Difference-Patterson hk0 projection for the derivative obtained with MHTS. The large peak at $[{1 \over 4}]$ , $[{1 \over 4}]$ is not explained by this solution (Fenn, 1964).

References

International Tables for Crystallography (2006). Vol. F. ch. 26.1, p. 747