International
Tables for
Crystallography
Volume F
Crystallography of biological macromolecules
Edited by M. G. Rossmann and E. Arnold

© International Union of Crystallography 2006
International Tables for Crystallography (2006). Vol. F. ch. 4.2, p. 97

Table 4.2.2.1 

H. Michela*

aMax-Planck-Institut für Biophysik, Heinrich-Hoffmann-Strasse 7, D-60528 Frankfurt/Main, Germany
Correspondence e-mail: michel@mpibp-frankfurt.mpg.de

Table 4.2.2.1 | top | pdf |
Potentially useful detergents for membrane-protein crystallizations with molecular weights and CMCs [in water, from Michel (1991) or as provided by the vendor]

The lengths of the alkyl or alkanoyl side chains are given as [\hbox{C}_{6}] to [\hbox{C}_{16}].

Detergent Molecular weight CMC (mM)
Alkyl dihydroxypropyl sulfoxide    
C8 238 20.6
N,N-Dimethylalkylamine-N-oxides    
C8 173 162
C9 187 50
C10 201 20
C12 229 1–2
n-Dodecyl-N,N-dimethylglycine (zwitterionic) 271 1.5
N-Alkyl-β-D-glucopyranosides    
C6 264 250
C7 278 79
C8 292 30
C9 306 6.5
C10 320 2.6
n-Alkanoyl-N-hydroxyethylglucamides (`HEGA-n')    
C8 351 109
C9 365 39
C10 379 7.0
C11 393 1.4
Alkyl hydroxyethyl sulfoxide    
C8 222 15.8
n-Alkyl-β-D-maltosides    
C6 426 210
C8 454 19.5
C9 468 6
C10 483 1.8
C11 497 0.6
C12 511 0.17
C13 525 0.033
C14 539 0.01
C16 567 0.006
cyclohexyl-C1 438 340
cyclohexyl-C2 452 120
cyclohexyl-C3 466 34.5
cyclohexyl-C4 480 7.6
cyclohexyl-C5 494 2.4
cyclohexyl-C6 508 0.56
cyclohexyl-C7 522 0.19
n-Alkanoyl-N-methylglucamides (`MEGA-n')    
C8 321 79
C9 335 25
C10 349 6
Methyl-6-O-(N-heptylcarbamoyl)-α-D-glucopyranoside (`HECAMEG') 335 19.5
n-Alkylphosphocholines (zwitterionic)    
C8 295 114
C9 309 39.5
C10 323 11
C12 315 1.5
C14 379 0.12
C16 407 0.013
Polyoxyethylene monoalkylethers (CnEm)    
C8E4 306 7.9
C8E5 350 7.1
C10E6 422 0.9
C12E8 538 0.071
n-Alkanoylsucrose    
C10 497 2.5
C12 525 0.3
n-Alkyl-β-D-thioglucopyranosides    
C7 294 29
C8 308 9
C9 322 2.9
C10 336 0.9
n-Alkyl-β-D-thiomaltopyranosides    
C8 471 8.5
C9 485 3.2
C10 499 0.9
C11 513 0.21
C12 527 0.05