International Tables for Crystallography

Access to online content requires a licence


You have followed a link to material from the 2012 edition of International Tables for Crystallography Volume F. If you would like to update your licence to include this material please contact support@iucr.org. If you have a licence for the 2006 edition of this volume please follow the link below to access material from it:

International Tables for Crystallography (2006). Vol. F, Section 12.1.3
The preparation of heavy-atom derivatives of protein crystals for use in multiple isomorphous replacement and anomalous scattering
D. Carvin, S. A. Islam, M. J. E. Sternberg and T. L. Blundell. International Tables for Crystallography (2012). Vol. F, ch. 12.1, pp. 317-326  [ doi:10.1107/97809553602060000837 ]

Abstract

In this chapter an introduction to the heavy-atom data bank is provided and strategies are reviewed that can be adopted in the preparation of heavy-atom derivatives of protein crystals for use in multiple isomorphous replacement and anomalous scattering. Topics covered include: heavy-atom derivatives and their complexes; amino acids as ligands; the protein chemistry of heavy-atom reagents; metal-ion replacement in metalloproteins; analogues of amino acids; and the use of the heavy-atom data bank to select derivatives.


Access, prices and ordering

International Tables for Crystallography is available online as a full set of volumes through Wiley.

set

If you have already registered and are using a computer listed in your registration details, please email support@iucr.org for assistance.

About International Tables for Crystallography

International Tables for Crystallography is the definitive resource and reference work for crystallography. The multi-volume series comprises articles and tables of data relevant to crystallographic research and to applications of crystallographic methods in all sciences concerned with the structure and properties of materials.