International Tables for Crystallography

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International Tables for Crystallography (2006). Vol. F, Figure 23.4.3.4
Solvent structure
C. Mattos and D. Ringe. International Tables for Crystallography (2012). Vol. F, ch. 23.5, pp. 800-820  [ doi:10.1107/97809553602060000894 ]

Abstract

This chapter summarises empirical information on the structure of water molecules bound to proteins. The focus is on structures solved by X-ray crystallography, although complementary techniques of obtaining solvent structure are discussed briefly and, when appropriate, particular examples are given. The coverage includes: methods by which solvent structure can be observed; knowledge derived from database analysis of large numbers of proteins; particular examples of groups of well studied protein structures; the contribution of protein models obtained at very high resolution to the understanding of solvent structure; and an analysis of water molecules as mediators of complex formation. Finally, a conclusion and a perspective is presented regarding the direction in which this information can lead in building a cohesive understanding of the roles played by solvent in the structural integrity and biological function of macromolecules.


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About International Tables for Crystallography

International Tables for Crystallography is the definitive resource and reference work for crystallography. The multi-volume series comprises articles and tables of data relevant to crystallographic research and to applications of crystallographic methods in all sciences concerned with the structure and properties of materials.