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The preparation of heavy-atom derivatives of protein crystals for use in multiple isomorphous replacement and anomalous scattering
Carvin, D., Islam, S. A., Sternberg, M. J. E. and Blundell, T. L.  International Tables for Crystallography (2012). Vol. F, ch. 12.1, pp. 317-326 [ doi:10.1107/97809553602060000837 ]
... 1954) and is often enhanced by anomalous scattering (MIRAS) [see Blundell & Johnson (1976) for a review]. The method remains popular ... with an amino acid modified by a heavy atom [see Blundell & Johnson (1976) for a review]. Alternatively, analogues of the ... extended in a comprehensive review of protein heavy-atom derivatives (Blundell & Johnson, 1976; Blundell & Jenkins, 1977) which analysed the dependence ...

Analogues of amino acids
Carvin, D., Islam, S. A., Sternberg, M. J. E. and Blundell, T. L.  International Tables for Crystallography (2012). Vol. F, Section 12.1.7, pp. 324-325 [ doi:10.1107/97809553602060000837 ]
... References Budisa, N., Karnbrock, W., Steinbacher, S., Humm, A., Prade, L., Neuefeind, T., Moroder, L. & Huber, R. (1997). Bioincorporation of telluromethionine into proteins: ...

Metal-ion replacement in metalloproteins
Carvin, D., Islam, S. A., Sternberg, M. J. E. and Blundell, T. L.  International Tables for Crystallography (2012). Vol. F, Section 12.1.6, p. 324 [ doi:10.1107/97809553602060000837 ]
Metal-ion replacement in metalloproteins 12.1.6. Metal-ion replacement in metalloproteins The metal-ion cofactor can sometimes be displaced by dialysis or diffusion by a heavy-atom solution, but usually the cofactor is first removed by a chelating agent (e.g. EDTA) or by acidification. These are best carried out on the ...

Polynuclear reagents
Carvin, D., Islam, S. A., Sternberg, M. J. E. and Blundell, T. L.  International Tables for Crystallography (2012). Vol. F, Section 12.1.5.7, p. 324 [ doi:10.1107/97809553602060000837 ]
... reviewed by Thygesen et al. (1996). References O'Halloran, T. V., Lippard, S. J., Richmond, T. J. & Klug, A. (1987). Multiple heavy-atom reagents for ...
     [more results from section 12.1.5 in volume F]

Amino acids as ligands
Carvin, D., Islam, S. A., Sternberg, M. J. E. and Blundell, T. L.  International Tables for Crystallography (2012). Vol. F, Section 12.1.4, pp. 320-321 [ doi:10.1107/97809553602060000837 ]
... to give useful derivatives. References Ely, K. R., Girling, R. L., Schiffer, M., Cunningham, D. E. & Edmundson, A. B. (1973). ... nm resolution, a new study of the complex of glycyl-L-tyrosine with CPA, and mechanistic deductions. Philos. Trans. R. Soc. ...

Effect of concentration, time of soak and temperature on heavy-atom binding
Carvin, D., Islam, S. A., Sternberg, M. J. E. and Blundell, T. L.  International Tables for Crystallography (2012). Vol. F, Section 12.1.3.7, p. 320 [ doi:10.1107/97809553602060000837 ]
... times more slowly at 4C than at ambient temperature (Blundell, 1968). A lower temperature allows greater control over the ... bind may do so upon elevation of the temperature. References Blundell, T. L. (1968). Unpublished results. Ringe, D., Petsko, G. ...
     [more results from section 12.1.3 in volume F]

Heavy-atom data bank
Carvin, D., Islam, S. A., Sternberg, M. J. E. and Blundell, T. L.  International Tables for Crystallography (2012). Vol. F, Section 12.1.2, pp. 317-318 [ doi:10.1107/97809553602060000837 ]
Heavy-atom data bank 12.1.2. Heavy-atom data bank The heavy-atom data bank (HAD) is a computer-based archival file system that contains experimental and derived information from successful multiple isomorphous replacement analyses in the determination of protein crystal structures. HAD is available at http://www.sbg.bio.ic.ac.uk/had/ . The data ...

Introduction
Carvin, D., Islam, S. A., Sternberg, M. J. E. and Blundell, T. L.  International Tables for Crystallography (2012). Vol. F, Section 12.1.1, p. 317 [ doi:10.1107/97809553602060000837 ]
... 1954) and is often enhanced by anomalous scattering (MIRAS) [see Blundell & Johnson (1976) for a review]. The method remains popular ... with an amino acid modified by a heavy atom [see Blundell & Johnson (1976) for a review]. Alternatively, analogues of the ... extended in a comprehensive review of protein heavy-atom derivatives (Blundell & Johnson, 1976; Blundell & Jenkins, 1977) which analysed the dependence ...

Use of the heavy-atom data bank to select derivatives
Carvin, D., Islam, S. A., Sternberg, M. J. E. and Blundell, T. L.  International Tables for Crystallography (2012). Vol. F, Section 12.1.8, p. 325 [ doi:10.1107/97809553602060000837 ]
Use of the heavy-atom data bank to select derivatives 12.1.8. Use of the heavy-atom data bank to select derivatives The heavy-atom data bank is probably best exploited by first investigating the most commonly used heavy-atom reagents with a view to obtaining mercury, platinum and uranyl derivatives that ...

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