Figure 23.2.4.5

Hodel, A. E.; Quiocho, F. A.

doi:10.1107/97809553602060000715

International
Tables for
Crystallography
Volume F
Crystallography of biological macromolecules
Edited by M. G. Rossmann and E. Arnold

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International Tables for Crystallography (2006). Vol. F. ch. 23.2, p. 584 | 1 | 2 |

Figure 23.2.4.5

A. E. Hodel^a ^‡ and F. A. Quiocho^b

^aDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA, and ^bHoward Hughes Medical Institute and Department of Biochemistry, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA

Figure 23.2.4.5

The specific recognition of the messenger RNA 7-methylguanosine cap. (a) The residues contacting the m⁷G base in the cap-binding protein, IF-4E (Marcotrigiano et al., 1997). (b) The residues interacting with the cap in the vaccinia RNA methyltransferase VP39 (Hodel et al., 1997). Both proteins bind to the charged, methylated base by stacking aromatic amino acids on both sides of the base.