Figure 23.3.4.5

Dickerson, R. E.

doi:10.1107/97809553602060000716

International
Tables for
Crystallography
Volume F
Crystallography of biological macromolecules
Edited by M. G. Rossmann and E. Arnold

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International Tables for Crystallography (2006). Vol. F. ch. 23.3, p. 604 | 1 | 2 |

Figure 23.3.4.5

R. E. Dickerson^a ^*

^a Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095–1570, USA
Correspondence e-mail: red@mbi.ucla.edu

Figure 23.3.4.5

DNA duplex (red and blue strands) looped around IHF or integration host factor. The two subunits of the IHF duplex are green and turquoise. Two antiparallel loops of protein chain, one from each subunit, insert into the minor groove of B-DNA at the sequence C-A-A-T/A-T-T-G and produce abrupt bends via local roll angles of 60°. The two localized bends are additive because they occur one helical turn apart. All other steps have roll angles of 5° or less. The two flanking helix segments pack against the IHF dimer and must be kept straight and unbent. This is accomplished in one of the two segments by an A-tract of sequence C-A-A-A-A-A-A-G. From Dickerson & Chiu (1997). Coordinates courtesy of P. Rice.