International Tables for Crystallography

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International Tables for Crystallography (2006). Vol. F, Section 14.1.7
Heavy-atom location and phase determination with single-wavelength diffraction data
B. W. Matthews. International Tables for Crystallography (2012). Vol. F, ch. 14.1, pp. 367-372  [ doi:10.1107/97809553602060000844 ]

Abstract

The information from anomalous scattering and isomorphous replacement are complementary. Ways in which these two sources of information can be combined to facilitate the determination of the crystal structures of macromolecules are reviewed. The use of a single isomorphous replacement leads to an ambiguous phase determination, but this ambiguity can be resolved by incorporation of data from anomalous scattering. Likewise, information from isomorphous replacement and anomalous scattering can be combined to assist in the location of heavy atoms.


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About International Tables for Crystallography

International Tables for Crystallography is the definitive resource and reference work for crystallography. The multi-volume series comprises articles and tables of data relevant to crystallographic research and to applications of crystallographic methods in all sciences concerned with the structure and properties of materials.