International Tables for Crystallography
Access to online content requires a licence
You have followed a link to material from the 2012
edition of International Tables for Crystallography
Volume F. If you would like to update your licence to
include this material please contact
support@iucr.org.
If you have a licence for the 2006 edition of this volume
please follow the link below to access material from it:
International Tables for Crystallography (2006). Vol. F, Section 23.1.2.3 |
Locating domains in three-dimensional structures International Tables for Crystallography (2012). Vol. F, ch. 23.2, pp. 752-754 [ doi:10.1107/97809553602060000891 ] Abstract The assignment of protein domains from three-dimensional structure is critically important in understanding protein evolution and function. Domains are quasi-independent substructures that are thought to fold autonomously, to carry specific molecular functions, to move relative to each other as semi-rigid bodies and to speed the evolution of new functions by recombination. The concepts underlying computational methods for locating domains in three-dimensional structures are presented. Early algorithms focused on physical criteria to identify compact subunits. With the growth of the structural database, the focus has shifted to methods for identifying recurrent substructures that can form the basis for a consistent protein-structure classification. |
Access, prices and ordering
International Tables for Crystallography is available online as a full set of volumes through Wiley.
If you have already registered and are using a computer listed in your registration details, please email support@iucr.org for assistance.
About International Tables for Crystallography
International Tables for Crystallography is the definitive resource and reference work for crystallography. The multi-volume series comprises articles and tables of data relevant to crystallographic research and to applications of crystallographic methods in all sciences concerned with the structure and properties of materials.