General methods
Sauter, C.,

Lorber, B.,

McPherson, A. and

Giegé, R.,

International Tables for Crystallography
(2012).
Vol. F,
ch. 4.1,
pp. 99-121

[ doi:10.1107/97809553602060000812 ]
has often been considered unpredictable, although it obeys the same principles as that of small molecules (Giegé et al., 1995 ;

**McPherson** et al., 1995 ; Rosenberger, 1996 ; Chernov, 2003 ;

**McPherson** & Giegé, 2007 ...

Growth and cessation of growth
Sauter, C.,

Lorber, B.,

McPherson, A. and

Giegé, R.,

International Tables for Crystallography
(2012).
Vol. F,
Section 4.1.5.2,
pp. 111-112

[ doi:10.1107/97809553602060000812 ]
contrast microscopy. Each of these methods provides complementary data which, in combination, have yielded answers to many relevant questions.
Time-lapse video microscopy has been used to measure growth rates (Koszelak &

**McPherson**, 1988 ; Lorber ...

[

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results from section 4.1.5 in volume F]

The future of protein crystal growth
Sauter, C.,

Lorber, B.,

McPherson, A. and

Giegé, R.,

International Tables for Crystallography
(2012).
Vol. F,
Section 4.1.7,
pp. 115-115

[ doi:10.1107/97809553602060000812 ]
...

Database mining and statistics
Sauter, C.,

Lorber, B.,

McPherson, A. and

Giegé, R.,

International Tables for Crystallography
(2012).
Vol. F,
Section 4.1.6.3,
pp. 114-115

[ doi:10.1107/97809553602060000812 ]
...

[

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results from section 4.1.6 in volume F]

Historical development of methods
Sauter, C.,

Lorber, B.,

McPherson, A. and

Giegé, R.,

International Tables for Crystallography
(2012).
Vol. F,
Section 4.1.3.1,
pp. 104-105

[ doi:10.1107/97809553602060000812 ]
methods
Protein crystallization is an old field that started more than 100 years ago (

**McPherson**, 1991). Early methods included protein extractions with salts or organic solvents, or dialysis of salt solutions against water ...

[

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results from section 4.1.3 in volume F]

Seeding
Sauter, C.,

Lorber, B.,

McPherson, A. and

Giegé, R.,

International Tables for Crystallography
(2012).
Vol. F,
Section 4.1.4.4,
pp. 110-111

[ doi:10.1107/97809553602060000812 ]
...

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results from section 4.1.4 in volume F]

Prologue
Sauter, C.,

Lorber, B.,

McPherson, A. and

Giegé, R.,

International Tables for Crystallography
(2012).
Vol. F,
Section 4.1.1.1,
pp. 99-99

[ doi:10.1107/97809553602060000812 ]
...

[

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results from section 4.1.1 in volume F]

Purity and homogeneity
Sauter, C.,

Lorber, B.,

McPherson, A. and

Giegé, R.,

International Tables for Crystallography
(2012).
Vol. F,
Section 4.1.2.4,
pp. 103-104

[ doi:10.1107/97809553602060000812 ]
specific aggregates, alter macromolecular solubility, or interfere with nucleation and crystal growth (

**McPherson** et al., 1996, 2004 ; Moreno et al., 2005 ; Thomas et al., 1998). These effects are reduced in gel media (Hirschler ...

[

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results from section 4.1.2 in volume F]