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 Results for DC.creator="R." AND DC.creator="A." AND DC.creator="Engh" in section 18.3.3 of volume F
Confidence in restraints versus information from diffraction
Engh, R. A. and Huber, R.  International Tables for Crystallography (2012). Vol. F, Section 18.3.3.1, p. 483 [ doi:10.1107/97809553602060000857 ]
Confidence in restraints versus information from diffraction 18.3.3.1. Confidence in restraints versus information from diffraction Primarily in cases of new structures, such as small-ligand- or metal-binding proteins, the refinement may indicate that the expected geometries and applied restraints seem incompatible with evidence from the electron density. Several sources for ...

Strategy of application during building/refinement
Engh, R. A. and Huber, R.  International Tables for Crystallography (2012). Vol. F, Section 18.3.3, p. 483 [ doi:10.1107/97809553602060000857 ]
... errors in fragment structures artifactually distorted the parameterization. References Laskowski, R. A., MacArthur, M. W., Moss, D. S. & Thornton, J. M. (1993). PROCHECK: a program to check the stereochemical quality of protein structures. ...

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