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 Results for DC.creator="W." AND DC.creator="G." AND DC.creator="J." AND DC.creator="Hol" in section 1.3.4 of volume F   page 1 of 2 pages.
Crystallography and development of novel pharmaceuticals
Hol, W. G. J. and Verlinde, C. L. M. J.  International Tables for Crystallography (2012). Vol. F, Section 1.3.4, pp. 15-26 [ doi:10.1107/97809553602060000806 ]
... up until the mid-1990s (Kuntz, 1992; Perutz, 1992; Verlinde & Hol, 1994; Whittle & Blundell, 1994; Charifson, 1997; Veerapandian, 1997). Possibly ... in their manufacture. References Achari, A., Somers, D. O., Champness, J. N., Bryant, P. K., Rosemond, J. & Stammers, D. K. (1997). Crystal structure of the ...

Drug metabolism and crystallography
Hol, W. G. J. and Verlinde, C. L. M. J.  International Tables for Crystallography (2012). Vol. F, Section 1.3.4.4, p. 25 [ doi:10.1107/97809553602060000806 ]
... Bruns, C. M., Hubatsch, I., Ridderstrom, M., Mannervik, B. & Tianer, J. A. (1999). Human glutathione transferase A4-4 crystal structures ... basis of high catalytic efficiency with toxic lipid peroxidation products. J. Mol. Biol. 288, 427-439. Carter, D. C. & Ho, J. X. (1994). Structure of serum albumin. Adv. Protein ...

Neurological disorders
Hol, W. G. J. and Verlinde, C. L. M. J.  International Tables for Crystallography (2012). Vol. F, Section 1.3.4.3.5, pp. 23-25 [ doi:10.1107/97809553602060000806 ]
Neurological disorders 1.3.4.3.5. Neurological disorders Even a quick glance at Table 1.3.4.5 shows that crystallography contributes to new therapeutics for numerous human afflictions and diseases. Yet there are major gaps in our understanding of protein functions, in particular of those involved in development and in neurological functions. These proteins are the ...

Cardiovascular disorders
Hol, W. G. J. and Verlinde, C. L. M. J.  International Tables for Crystallography (2012). Vol. F, Section 1.3.4.3.4, p. 23 [ doi:10.1107/97809553602060000806 ]
... are in clinical trials (Pineo & Hull, 1999). References Pineo, G. F. & Hull, R. D. (1999). Thrombin inhibitors as anticoagulant agents. Curr. Opin. Hematol. 6, 298-303. Ripka, W. C. (1997). Design of antithrombotic agents directed at factor ...

Blindness
Hol, W. G. J. and Verlinde, C. L. M. J.  International Tables for Crystallography (2012). Vol. F, Section 1.3.4.3.3, p. 23 [ doi:10.1107/97809553602060000806 ]
... for glaucoma: dorzolamide (Baldwin et al., 1989). References Baldwin, J. J., Ponticello, G. S., Anderson, P. S., Christy, M. E., Murcko, M. ...

Diabetes
Hol, W. G. J. and Verlinde, C. L. M. J.  International Tables for Crystallography (2012). Vol. F, Section 1.3.4.3.2, p. 23 [ doi:10.1107/97809553602060000806 ]
... life of millions of people (Brange, 1997). References Brange, J. (1997). The new era of biotech insulin analogues. Diabetologia, 40, S48-S53. Derewenda, U., Derewenda, Z., Dodson, E. J., Dodson, G. G., Reynolds, C. D., Smith, G. D., Sparks, C. & ...

Cancers
Hol, W. G. J. and Verlinde, C. L. M. J.  International Tables for Crystallography (2012). Vol. F, Section 1.3.4.3.1, pp. 22-23 [ doi:10.1107/97809553602060000806 ]
... design of anti-neoplastic agents. References Amos, L. A. & Lowe, J. (1999). How Taxol stabilises microtubule structure. Chem. Biol. 6 ... M., Tong, L., Milburn, M. V., Matias, P. M., Jancarik, J., Noguchi, S., Nishimura, S., Miura, K., Ohtsuka, E. & Kim, S. ... Natl Acad. Sci. USA, 82, 1376-1380. Krengel, U., Petsko, G. A., Goody, R. S., Kabsch, W. & Wittinghofer, A. (1990) ...

Non-communicable diseases
Hol, W. G. J. and Verlinde, C. L. M. J.  International Tables for Crystallography (2012). Vol. F, Section 1.3.4.3, pp. 22-25 [ doi:10.1107/97809553602060000806 ]
... crystallography in the 21st century. References Amos, L. A. & Lowe, J. (1999). How Taxol stabilises microtubule structure. Chem. Biol. 6, R65-R69. Baldwin, J. J., Ponticello, G. S., Anderson, P. S., Christy, M. E., ...

Resistance
Hol, W. G. J. and Verlinde, C. L. M. J.  International Tables for Crystallography (2012). Vol. F, Section 1.3.4.2, pp. 18-22 [ doi:10.1107/97809553602060000806 ]
... References Bussiere, D. E., Pratt, S. D., Katz, L., Severin, J. M., Holzman, T. & Park, C. H. (1998). The structure ... vancomycin resistance. Mol. Cell, 2, 75-84. Das, K., Ding, J., Hsiou, Y., Clark, A. D. Jr, Moereels, H., Koymans, L., Andries, K., Pauwels, R., Janssen, P. A. J., Boyer, P. L., Clark, P., Smith, R. H. Jr, ...

Helminths
Hol, W. G. J. and Verlinde, C. L. M. J.  International Tables for Crystallography (2012). Vol. F, Section 1.3.4.1.5, p. 18 [ doi:10.1107/97809553602060000806 ]
Helminths 1.3.4.1.5. Helminths Worms affect the lives of billions of human beings, causing serious morbidity in many ways. Onchocerca volvolus is the cause of river blindness, which resulted in the virtual disappearance of entire villages in West Africa, until ivermectin appeared. This remarkable compound dramatically reduced the incidence of the disease ...

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