International
Tables for Crystallography Volume F Crystallography of biological macromolecules Edited by M. G. Rossmann and E. Arnold eISBN 1-4020-5416-5 © International Union of Crystallography 2006 |
International Tables for Crystallography (2006). Vol. F, ch. 17.2,
p. 365
Figure 17.2.5.1 aThe Scripps Research Institute, La Jolla, CA 92037, USA |
|
Figure 17.2.5.1
This image represents a volume of blood plasma 750 Å on a side. Within the three-dimensional model, antibodies (Y- and T-shaped molecules in light blue and pink) are binding to a virus (the large green spherical assembly on the right), labelling it for destruction. It shows all macromolecules present in the blood plasma at a magnification of about 10 000 000 times. This model is composed of over 450 individual protein domains, ranging in size from the 60 protomers making up the poliovirus to a single tiny insulin molecule (in magenta). The model was constructed using atomic level descriptions for each molecule, for a total of roughly 1.5 million atoms. Detailed surfaces were computed for each type of protein using MSMS by Michel Sanner and then smoothed to a lower resolution using the HARMONY spherical-harmonic surfaces developed by Bruce Duncan. The model geometry contains over 1.5 million triangles. |