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International
Tables for Crystallography Volume B Reciprocal space Edited by U. Shmueli © International Union of Crystallography 2006 |
International Tables for Crystallography (2006). Vol. B. ch. 3.3, p. 382
Section 3.3.3.2.5. Texas A&M University system
aMRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, England |
This system (Morimoto & Meyer, 1976![[link]](/graphics/greenarr.gif)
), a development of Meyer's earlier system (Section 3.3.3.1), uses vector-graphics technology and a minicomputer and is free of the timing restrictions of the earlier system. The system allows control dials to be dynamically coupled by software to rotations or translations of parts of the structure, thus permitting the re-shaping or re-positioning of the model to suit an electron-density map which may be contoured and managed by the minicomputer host. The system may be used to impose idealized geometry, such as planar peptides in proteins, or it may work with non-idealized coordinates.
The system was successfully applied to the structures of rubredoxin and the extracellular nuclease of Staphylococcus aureus (Collins et al., 1975) and to binding studies of sulfonamides to carbonic anhydrase (Vedani & Meyer, 1984). In addition, two of the first proteins to be constructed without the aid of a `Richards' Box' were modelled on this system: monoclinic lysozyme in 1976 (Hogle et al., 1981) and arabinose binding protein in 1978 (Gilliland & Quiocho, 1981).
References
Collins, D. M., Cotton, F. A., Hazen, E. E., Meyer, E. F. & Morimoto, C. N. (1975). Protein crystal structures: quicker, cheaper approaches. Science, 190, 1047–1053.Google Scholar
Gilliland, G. L. & Quiocho, F. A. (1981). Structure of the L-arabinose-binding protein from Escherichia coli at 2.4 Å resolution. J. Mol. Biol. 146, 341–362.Google Scholar
Hogle, J., Rao, S. T., Mallikarjunan, M., Beddell, C., McMullan, R. K. & Sundaralingam, M. (1981). Studies of monoclinic hen egg white lysozyme. Structure solution at 4 Å resolution and molecular-packing comparisons with tetragonal and triclinic lysozymes. Acta Cryst. B37, 591–597.Google Scholar
Morimoto, C. N. & Meyer, E. F. (1976). Information retrieval, computer graphics, and remote computing. In Crystallographic computing techniques, edited by F. R. Ahmed, K. Huml & B. Sedlacek, pp. 488–496. Copenhagen: Munksgaard.Google Scholar
Vedani, A. & Meyer, E. F. (1984). Structure–activity relationships of sulfonamide drugs and human carbonic anhydrase C: modelling of inhibitor molecules into receptor site of the enzyme with an interactive computer graphics display. J. Pharm. Sci. 73, 352–358.Google Scholar
