Figure 23.3.4.4

Dickerson, R. E.

doi:10.1107/97809553602060000716

International
Tables for
Crystallography
Volume F
Crystallography of biological macromolecules
Edited by M. G. Rossmann and E. Arnold

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International Tables for Crystallography (2006). Vol. F. ch. 23.3, p. 604 | 1 | 2 |

Figure 23.3.4.4

R. E. Dickerson^a ^*

^a Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095–1570, USA
Correspondence e-mail: red@mbi.ucla.edu

Figure 23.3.4.4

Structure of the 2:1 complex of a di-imidazole lexitropsin with C-A-T-G-G-C-C-A-T-G (B108). The drug now is represented by $[\hbox{H---CONH---Im---CONH---Im---CONH---CH}_{2}\hbox{---CH}_{2}\hbox{---C}(\hbox{NH}_{2})_{2}^{+}]$ where Im is a five-membered imidazole ring, or again more compactly by ⁰=Im=Im=⁺. The uncharged leading amide group, characteristic of distamycins, is identified by ⁰. Distamycin itself would be represented in this shorthand notation by ⁰=Py=Py=Py=⁺. Reprinted from B108, copyright (1977), with permission from Excerpta Medica Inc.